Neurological complications may affect a minority of those with Sjögren’s disease, around 10-20%, and range from cognitive difficulties to differences in extremity sensation and pain. Various types and severities of neuropathy can manifest in Sjögren’s disease, and a thorough evaluation and testing are needed prior to diagnosis.
Non-Vasculitic Peripheral & Cranial Neuropathies
These can be managed first with tricyclic antidepressants or anti-epileptics (e.g. gabapentin, pregabilin, carbamazepine). For individuals who fail to respond, intravenous immunoglobulin (0.4 g/kg/d for 5 days) may be beneficial.
Vasculitic Neuropathies
These are typically treated with corticosteroids and cyclophosphamide, although the drug Rituximab is gaining wider acceptance as an alternative to cyclophosphamide.
