• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer

Johns Hopkins Sjögren’s Center

Show Search
Hide Search
  • Sjögren’s Syndrome Information
    • Diagnosis of Sjögren’s Syndrome
    • Sjögren’s Syndrome Symptoms
    • Treatment of Sjögren’s Syndrome
    • Sjögren’s Syndrome Disease Education Series
  • About the Center
    • Meet Our Team
    • Schedule An Appointment
    • Physician Referral Information
    • Directions
  • Research
  • Support the Center
  • Contact Us
Home / Research

Research

Clinical Trials

  • A 48-week, 6-arm, randomized, double-blind, placebo-controlled multicenter trial to assess the safety and efficacy of multiple CFZ533 doses administered subcutaneously in two distinct populations of patients with Sjögren’s Syndrome (TWINSS) (Enrollment Complete)
  • A phase 2 randomized, double-blind, placebo-controlled, proof of concept study to evaluate the efficacy and safety of VIB4920 in subjects with Sjögren’s syndrome (SS) (Enrollment Complete)
  • A randomized, double-blind, placebo controlled, multicenter phase III study to assess the efficacy and safety of ianalumab in patients with active Sjögren’s syndrome (NEPTUNUS) (Coming Soon)

Other Research Studies

Longitudinal Study of a Prospective Cohort of Patients with Sjögren’s Syndrome

Dr. Alan Baer has established a Sjögren’s syndrome cohort in the Jerome L. Greene Sjögren’s Syndrome Center. Information is being collected about the clinical history and long-term disease progression of patients with suspected or established Sjögren’s syndrome. Questionnaires, sera and salivary glands are collected upon entry into the study.  Questionnaires are distributed electronically every 3 months and sera is collected bi-annually and stored for future studies. This cohort consists of over one thousand participants and continues to grow.

Sjögren’s Syndrome Screening Dry Eye Study (SSDE Study)

  • PI: Dr. Alan Baer
  • Co-Investigator: Dr. Esen Akpek

Sjögren’s syndrome is a systemic autoimmune disorder characterized by lymphocytic infiltration of the salivary and lacrimal glands and other organs along with systemic production of autoantibodies. The involvement of salivary and lacrimal glands leads to progressive decreases in the quantity and quality of saliva and tears and impaired quality of life. Local treatment of the dry eyes and mouth can prevent complications, but does not appear to alter the course of the disease. Early diagnosis and implementation are critical in improving patients’ quality of life and treating complications.

Patients often first present to ophthalmologist with complaints of dry eye, and as a result ophthalmologists are in a unique position to screen patients for possible Sjögren’s syndrome. However, currently there are no evidence-based screening tools for ophthalmologists to use to identify patients with a high likelihood of having Sjögren’s syndrome. The central hypothesis of this research is that using a screening algorithm comprised of a combination of questionnaire responses, autoantibody tests and standard dry eye exam findings will stratify dry eye patients into those having high, medium or low likelihood of having Sjögren’s syndrome.

If you have questions about any of the research being done at the center, please contact Susan Robinson, Research Coordinator via email at srobin95@jhmi.edu or phone 410-550-6492.

Receive the Latest News from Johns Hopkins Rheumatology

Receive the Latest News from Johns Hopkins Rheumatology

Join our mailing list to receive the latest news and updates from Johns Hopkins Rheumatology.

Interested In

You have Successfully Subscribed!

Use of this Site

All information contained within the Johns Hopkins Jerome L. Green Sjogren’s Center website is intended for educational purposes only. Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained within this site. Consumers should never disregard medical advice or delay in seeking it because of something they may have read on this website.

Primary Sidebar

Jerome L. Greene Sjögren’s Syndrome Center Information

  • About Us
  • Meet Our Team
  • Physician Referral Information
  • Schedule An Appointment
  • Contact
  • Directions

Dr. Alan Baer in Chair in Front of Brick Wall Discussing Sjögren’s Syndrome

In this five-part video series on Sjögren’s syndrome, Dr. Alan Baer validates those who suffer from this disease, and informs those who don’t, about the common misconceptions and challenges that Sjögren’s syndrome patients face every day.

Footer

Johns Hopkins Rheumatology

  • Johns Hopkins Rheumatology
  • Johns Hopkins Arthritis Center
  • Johns Hopkins Lupus Center
  • Johns Hopkins Lyme Disease Research Center
  • Johns Hopkins Myositis Center
  • Johns Hopkins Scleroderma Center
  • Johns Hopkins Vasculitis Center

Connect With Us

  • Facebook
  • Twitter
  • YouTube
U.S. News and World Report Rankings Badge

Johns Hopkins Medicine

© 2022 Johns Hopkins Jerome L. Greene Sjogren's Syndrome Center
Patient Privacy